U.S., Jan. 22 -- ClinicalTrials.gov registry received information related to the study (NCT07356765) titled 'Berberine in Treating Negative Symptoms of Schizophrenia: Clinical Efficacy and Mechanisms' on Jan. 13.
Brief Summary: "Negative" symptoms are a major challenge for people with schizophrenia (SZ) and are a key reason why they struggle with everyday functioning. While current medications work well for the "positive" symptoms (like hallucinations or delusions), they aren't very effective at improving these "negative" symptoms, which include things like a lack of motivation or emotion. This study plans to conduct a large, randomized, double-blind, placebo-controlled trial to see if a compound called berberine (BBR) can safely and effec...