U.S., March 19 -- ClinicalTrials.gov registry received information related to the study (NCT07481461) titled 'Altered Joint Mechanics and Biological Response in Osteoarthritic Knees.' on March 13.
Brief Summary: Osteoarthritis (OA) stands out as the most prevalent joint disease. It manifests as a progressive degradation of articular cartilage, new bone growth and often synovial tissue proliferation, resulting in pain and compromised joint functionality, ultimately leading to disability. Misalignment of the lower limb (varus or valgus knees) are recognised as a risk factor for osteoarthritis onset and progression. High tibial osteotomy (HTO) is a surgical technique that allows to shift the load from the affected area to other areas with int...