Clinical Trial: Adjunctive Melatonin Gel With MINST on GCF Galectin-3 and IL-1 in Stage III-IV Periodontitis

U.S., Nov. 10 -- ClinicalTrials.gov registry received information related to the study (NCT07926282) titled 'Adjunctive Melatonin Gel With MINST on GCF Galectin-3 and IL-1 in Stage III-IV Periodontitis' on Nov. 03.

Brief Summary: The goal of this clinical trial is to learn if adding melatonin gel to standard deep cleaning of the gums improves healing in adults with Stage III or IV periodontitis (advanced gum disease).

The main questions it aims to answer are:

* Does melatonin gel placed in the gum pockets improve the attachment of the gums to the teeth (clinical attachment level) more than deep cleaning alone?

* Does melatonin gel reduce gum pocket depth, plaque, bleeding, and inflammatory markers (Galectin-3 and IL-1) in gum fluid?

Re...