Clinical Trial: A Phase 2, Placebo-Controlled Study of Oral RXC008 for Crohn's Strictures

U.S., Sept. 23 -- ClinicalTrials.gov registry received information related to the study (NCT07832435) titled 'A Phase 2, Placebo-Controlled Study of Oral RXC008 for Crohn's Strictures' on Sept. 16.

Brief Summary: Crohn's disease (CD) is chronic inflammatory bowel disease where any part of the Gastrointestinal (GI) tract can become inflamed and develop fibrotic strictures. Intestinal strictures cause abdominal distension, cramping, dietary restrictions, nausea, vomiting, abdominal pain, and postprandial abdominal pain, which significantly impact patient quality of life.

Rho-associated coiled-coil kinase (ROCK) family of proteins including ROCK1 and ROCK2 have been shown to play an important role in these fibrotic strictures. The investigat...