Singapore, July 21 -- A "precision guided" CAR T-cell therapy designed at Peter MacCallum Cancer Centre, Australia's only public health service dedicated to caring for people affected by cancer, to kill solid tumours will progress to a first-in-human clinical trial.

This project, led by Professors Paul Beavis and Jane Oliaro, has received a $17.7 million Frontier Health and Medical Research Grant from the Medical Research Future Fund (MRFF).

The novel "precision guided" CAR T-cell therapy will be clinically trialled first in a blood cancer (multiple myeloma) as a validating step towards a later trial in solid tumours, likely in breast or lung cancer.

Compared to conventional CAR T-cells, the Precision Guided Munition (PGM) CAR T-cells ...