Cincinnati, Aug. 16 -- Thiago Agustin Tirante secured the biggest win of his career, ousting a physically struggling Serbian legend Novak Djokovic in the second round of the Cincinnati Open.

On Saturday, Thiago managed to keep his calm against the Serbian icon, beating him 2-6, 6-4, 6-4 after being one set down at the hard-court ATP Masters 1000 event. Tirant, the world number 50 in the ATP Rankings, took control in the second set. This was Djokovic's first competitive match since the Wimbledon semifinal against Jannik Sinner in July.

Despite Djokovic saving 13 of the 15 break points he faced, Tirante managed to find his way past the world number five and maximise on his lapses. The three-time Cincinnati champion Djokovic gained some en...