Clinical Trial: Multimodal Pharmacological Study of Clinical Cohorts for Major Depressive Disorder

U.S., May 23 -- ClinicalTrials.gov registry received information related to the study (NCT07602153) titled 'Multimodal Pharmacological Study of Clinical Cohorts for Major Depressive Disorder' on May 17.

Brief Summary: This study focuses on the neurobiological changes in MDD patients with high suicidal risk during rapid antidepressant treatments, such as Esketamine and Electroconvulsive Therapy (ECT). Core ObjectivesEstablish a standardized longitudinal cohort for high-risk suicidal populations to ensure high-quality data for clinical transformation. Investigate the biological mechanisms of rapid-acting interventions by analyzing changes in brain function and molecular pathways. Develop predictive biomarkers to identify treatment responders...